Cai LabWe have pioneered the field of single cell spatial genomics, gaining unprecedented insights into the molecular and spatial organization of organisms.
What drives us?
Biology is defined by spatial organization at many scales, ranging from meters – the size of the human body – to nanometers (billionths of a meter) – the size of molecules. We develop and utilize breakthrough technologies that allow us to observe the organization inside cells and the processes that drive cell functions.
Our methods answer the technical challenge of how to comprehensively image cell activity within its native environment. We’re able to apply our technologies to some of the most challenging problems in developmental biology, immunology, neuroscience, cancer biology, and microbiology.
Cai Lab developed seqFISH, a novel imaging technology that allows us to simultaneously visualize tens of thousands of different molecules in a single tissue sample. To achieve this level of molecular information, we combine fluorescence microscopy, DNA labeling nanotechnology, custom fluid handling, and advanced image processing.
In collaboration with the Elowitz Lab at Caltech, we’ve developed MEMOIR – a system that allows us to record cell lineage information and event histories in vivo that can subsequently be readout in situ by seqFISH.
Take a look at the latest work from Cai Lab now in Nature. The work describes a new "single-cell multimodal imaging approach where genome...
Preprint: Global architecture of the nucleus in single cells by DNA seqFISH+ and multiplexed immunofluorescence
Check out our latest preprint with seqFISH-based integrated spatial genomics approach to study chromosome organization, transcriptional states, and...
Congratulations to Elsy Buitrago-Delgado for being named one of Cell's 100 Inspiring Hispanic/Latinx Scientists in America! Her research studying...
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We are excited to hear from you. If you have any questions about our work, our lab, or want to collaborate, please send us a message.