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Our paper “Single-cell nuclear architecture across cell types in the mouse brain” published in Science

Our paper “Single-cell nuclear architecture across cell types in the mouse brain” published in Science

Nov 1, 2021 | Publications

Our latest work is now available in print inside the latest issue of Science. Using integrated spatial genomics technology, researchers at Cai Lab  extensively investigated the single-cell nuclear architecture across cell types in the mouse brain cortex. Take a look...
New publication ” Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis”

New publication ” Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis”

Sep 10, 2021 | Publications

Exciting new work “Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis” is now out in Nature Biotechnology! This publication details a new method for studying cell fate decisions in complex tissues during development....
New paper in Nature “Integrated spatial genomics reveals global architecture of single nuclei””

New paper in Nature “Integrated spatial genomics reveals global architecture of single nuclei””

Jan 28, 2021 | Publications

Take a look at the latest work from Cai Lab now in Nature. The work describes a new “single-cell multimodal imaging approach where genome organization, nuclear bodies, chromatin modifications and gene expression are determined in the same cell.” -Nature...
Preprint: Global architecture of the nucleus in single cells by DNA seqFISH+ and multiplexed immunofluorescence

Preprint: Global architecture of the nucleus in single cells by DNA seqFISH+ and multiplexed immunofluorescence

Dec 1, 2020 | Announcements, Publications

Check out our latest preprint with seqFISH-based integrated spatial genomics approach to study chromosome organization, transcriptional states, and chromatin states in single cells!  biorxiv.org  
New Publication: Detecting Proteins In Situ with DUET

New Publication: Detecting Proteins In Situ with DUET

Aug 3, 2020 | Announcements, Publications

Exciting new work by Cai Lab and lead author Yandong Zhang demonstrates a strategy for measuring proteins and their post-translational modification (PTM) states in single cells. From the paper: “Unlike nucleic acids, proteins cannot be amplified, making...
New Super-Resolution Technique Published in Nature

New Super-Resolution Technique Published in Nature

Mar 28, 2019 | Announcements, In the News, Publications

Work at Cai lab published by first author Chee Huat (Linus) Eng in the March 25, 2019 issue of Nature. Also featured in  Caltech News this week, the paper describes the novel RNA seqFISH+ technique for super-resolved imaging of the transcriptome in situ.  Caltech News...

Recent Posts

  • Long Cai receives NIH Director’s Pioneer Award
  • Cai Lab BBQ 2022
  • News feature: Revealing chromosome contours, one dot at a time
  • Our paper “Single-cell nuclear architecture across cell types in the mouse brain” published in Science
  • Presentation video: Integrated spatial genomics reveals invariant features in the nucleus

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