Cai Lab News
Long Cai receives NIH Director’s Pioneer Award
NIH has announced Long Cai is a recipient of its prestigious Pioneer Award. This award from the High-Risk, High Reward Research Program supports individual scientists "with outstanding records of creativity pursuing new research directions to develop pioneering...
Cai Lab BBQ 2022
Spring is in full swing on the Caltech campus and Cai Lab is celebrating! Leaving our bench work behind, the whole team had a much needed break beneath the trees at Tournament Park. Our resident amateur chef-scientists cooked up an impressive and massive BBQ feast -...
News feature: Revealing chromosome contours, one dot at a time
Nature interviews Cai Lab in this week's Technology Feature. In a vivid review article, Long Cai, along with Mitch Guttman (Caltech) and peers, describe how in situ microscopy works jointly with proximity ligation and sequencing to expand our understanding of the 3D...
Our paper “Single-cell nuclear architecture across cell types in the mouse brain” published in Science
Our latest work is now available in print inside the latest issue of Science. Using integrated spatial genomics technology, researchers at Cai Lab extensively investigated the single-cell nuclear architecture across cell types in the mouse brain cortex. Take a look...
Presentation video: Integrated spatial genomics reveals invariant features in the nucleus
Looking to delve into how integrated spatial genomics is revealing new insights in nuclear protein arrangement and function? You can watch a complete recording of Long Cai's talk at this years Single-Cell Proteomics Conference, SPC2021.
New publication ” Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis”
Exciting new work "Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis" is now out in Nature Biotechnology! This publication details a new method for studying cell fate decisions in complex tissues during development. Take a look...
Congrats to Dr. Takei and Dr. Eng on their defense!
Cai Lab is thrilled to celebrate the hard work and accomplishments of our two lab members graduating today. Dr. Yodai Takei, who's recent work uses imaging-based single-cell measurements to describe newly observed nuclear architectures, successfully defended his...
Preprint: “Integrated spatial genomics in tissues reveals invariant and cell type dependent nuclear architecture”
Our latest work "Integrated spatial genomics in tissues reveals invariant and cell type dependent nuclear architecture" is available to view as a preprint. We utilized imaging-based single-cell multimodal measurements to understand nuclear architectures inside the...
Cai Lab has a new home!
We're thrilled to make the move to the brand new Chen Neuroscience Research Building. We're already feeling at home in this beautiful, modern lab space. The new research hub brings together labs from across 6 divisions at Caltech. Read about the new interdisciplinary...
“Nuclear Physics”: Imaging into the Heart of a Cell
Delve into the big ideas of Cai Lab's latest research in this interview with authors Yodai Takei and Long Cai. Read the article at caltech.edu "The advantage of seqFISH+ is that it can actually see the intact nuclear structure at high resolution. While previous...